microRNA Binding Sites

The following 15 microRNA binding sites are avoided when the Avoid microRNA binding sites switch is checked.

microRNA	miRBase accession	Sequence	Seed (position 2-8)	mRNA binding site	Expression note
hsa-let-7a-5p	MIMAT0000062	UGAGGUAGUAGGUUGUAUAGUUU	GAGGUAG	CUACCUC	Highest-abundance family in most adult organs
hsa-miR-16-5p	MIMAT0000069	UAGCAGCACGUAAAUAUUGGCG	AGCAGCA	UGCUGCU	Standard housekeeping normaliser
hsa-miR-21-5p	MIMAT0000076	UAGCUUAUCAGACUGAUGUUGACU	AGCUUAU	AUAAGCU	Top-abundance in nearly all organs
hsa-miR-23a-3p	MIMAT0000078	AUCACAUUGCCAGGGAUUUCCAA	UCACAUU	AAUGUGA	Abundant across all tissues in multiple atlases
hsa-miR-24-3p	MIMAT0000080	UGGCUCAGUUCAGCAGGAACAG	GGCUCAG	CUGAGCC	Co-abundant with miR-23/27 cluster
hsa-miR-92a-3p	MIMAT0000092	UAUUGCACUUGUCCCGGCCUGU	AUUGCAC	GUGCAAU	Abundant and broad
hsa-miR-26a-5p	MIMAT0000082	UUCAAGUAAUCCAGGAUAGGCU	UCAAGUA	UACUUGA	Classified ubiquitous in cell-type-resolved data
hsa-miR-27a-3p	MIMAT0000084	UUCACAGUGGCUAAGUUCCGC	UCACAGU	ACUGUGA	Abundant and broad
hsa-miR-29a-3p	MIMAT0000086	UAGCACCAUCUGAAAUCGGUUA	AGCACCA	UGGUGCU	Broad and high; genuinely lower in brain
hsa-miR-30a-5p	MIMAT0000087	UGUAAACAUCCUCGACUGGAAG	GUAAACA	UGUUUAC	miR-30d/e ubiquitous; seed shared across family
hsa-miR-99a-5p	MIMAT0000097	AACCCGUAGAUCCGAUCUUGUG	ACCCGUA	UACGGGU	Broad; highest in kidney and lung
hsa-miR-103a-3p	MIMAT0000101	AGCAGCAUUGUACAGGGCUAUGA	GCAGCAU	AUGCUGC	Demonstrated ubiquitous across primary cell types
hsa-miR-125b-5p	MIMAT0000423	UCCCUGAGACCCUAACUUGUGA	CCCUGAG	CUCAGGG	Broad; skewed to brain, muscle, prostate
hsa-miR-148a-3p	MIMAT0000243	UCAGUGCACUACAGAACUUUGU	CAGUGCA	UGCACUG	Broad; highest in liver, GI, thyroid
hsa-miR-378a-3p	MIMAT0000732	ACUGGACUUGGAGUCAGAAGGC	CUGGACU	AGUCCAG	Broad; skewed to muscle, heart, adipose